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Oral Cavity Cancer includes cancers that develop anywhere in the mouth, such as the lips, tongue, gums, inner cheeks, floor of the mouth (under the tongue), hard palate (roof), and the area behind the wisdom teeth.
Uterine cancer is a type of cancer that originates in the uterus, the hollow, pear-shaped organ in a woman’s pelvis where fetal development takes place during pregnancy. It is one of the most common gynecological cancers, with the majority of cases occurring in postmenopausal women.
The two primary types of uterine cancer are:
Endometrial Cancer: Begins in the lining of the uterus (endometrium) and is the most common type.
Uterine Sarcoma: A rarer form that starts in the muscle layer (myometrium) or connective tissues.
Early detection plays a critical role in successful outcomes. Understanding how uterine cancer develops and what risk factors are involved is essential for early diagnosis and prevention.
Uterine cancer develops when genetic mutations occur in the DNA of uterine cells, causing them to multiply abnormally and avoid natural cell death. Over time, these cells accumulate to form a mass or tumor, which can invade nearby tissues and metastasize to other parts of the body if left untreated.
Several factors may contribute to the development of uterine cancer:
Hormonal Imbalance: High estrogen levels without adequate progesterone.
Age: Most cases are diagnosed in women over 50.
Obesity: Increases estrogen production and cancer risk.
Diabetes: Linked to a higher risk of endometrial cancer.
Genetics: Family history of uterine or colorectal cancer, especially Lynch syndrome.
Previous Radiation Therapy: Exposure to pelvic radiation may increase risk.
Reproductive History: Never having been pregnant, early menstruation, or late menopause.
Hormone Replacement Therapy (HRT): Especially estrogen-only HRT.
Stages:
Stage I: Confined to the uterus.
Stage II: Spread to the cervix.
Stage III: Spread to surrounding pelvic tissues.
Stage IV: Spread beyond the pelvis to distant organs.
Grades:
Grade 1 (Low Grade): Cells resemble normal cells and grow slowly.
Grade 2 (Intermediate Grade): More abnormal, moderate growth.
Grade 3 (High Grade): Highly abnormal and aggressive.
Endometrioid Adenocarcinoma
Uterine Papillary Serous Carcinoma
Clear Cell Carcinoma
Carcinosarcoma
Uterine Sarcoma
Early Signs:
Abnormal uterine bleeding
Unusual vaginal discharge
Pelvic pain
Advanced Symptoms:
Pain during intercourse
Unexplained weight loss
Fatigue
Difficulty urinating
Consult a Specialist: Prompt consultation with a gynecologic oncologist is essential if symptoms persist.
Initial Steps:
Symptom review and medical history
Physical and pelvic examination
Imaging Tests:
Transvaginal Ultrasound
MRI
CT Scan
PET Scan
Biopsies:
Endometrial Biopsy (Gold Standard)
Dilation and Curettage (D&C)
Staging:
Additional imaging and lab work to determine the extent of spread
At Konkan Cancer Centre, treatment is customized based on stage, grade, and overall health.
1. Surgery:
Hysterectomy (total or radical)
Bilateral Salpingo-Oophorectomy
Lymph Node Dissection
2. Radiation Therapy:
External Beam Radiation Therapy (EBRT)
Brachytherapy
3. Chemotherapy:
Often used in advanced stages or with high-grade tumors
4. Hormone Therapy:
Progestins, Tamoxifen, Aromatase Inhibitors
5. Targeted Therapy:
Targeting specific cancer cell markers
Gold Standard Treatment:
For early-stage: Surgery (Hysterectomy + Salpingo-Oophorectomy)
For advanced stages: Surgery + Radiation + Chemotherapy
While not completely preventable, risk can be reduced through lifestyle changes, managing chronic diseases, and regular gynecological check-ups.
Some cases are linked to hereditary syndromes like Lynch syndrome. Genetic counseling is advised if there’s a family history.
Estrogen-only HRT can increase risk. Combined HRT (with progesterone) has a lower risk.
Treatment may cause fatigue, nausea, hair loss, and infection susceptibility. Side effects are managed by your care team.
Initially every 3-6 months, then yearly, based on your oncologist’s advice.
A balanced, anti-inflammatory diet supports healing. Avoid processed foods and stay hydrated.
Fertility is impacted by most treatments. Discuss fertility preservation options before beginning treatment.
Konkan Cancer Centre offers emotional counseling, patient navigation, and support groups.
Uterine cancer, particularly endometrial cancer, can often be treated successfully when caught early. Awareness of symptoms, prompt medical consultation, and a personalized treatment approach significantly improve outcomes.
At Konkan Cancer Centre, we are dedicated to delivering state-of-the-art, compassionate care to every patient. If you or a loved one is experiencing symptoms or has been diagnosed with uterine cancer, contact our team today for expert evaluation and treatment.
Konkan Cancer Centre — Your Partner in Cancer Care.