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Uterine Cancer

Oral Cavity Cancer includes cancers that develop anywhere in the mouth, such as the lips, tongue, gums, inner cheeks, floor of the mouth (under the tongue), hard palate (roof), and the area behind the wisdom teeth.

Uterine Cancer

Overview of Uterine Cancer

Uterine cancer is a type of cancer that originates in the uterus, the hollow, pear-shaped organ in a woman’s pelvis where fetal development takes place during pregnancy. It is one of the most common gynecological cancers, with the majority of cases occurring in postmenopausal women.

The two primary types of uterine cancer are:

  • Endometrial Cancer: Begins in the lining of the uterus (endometrium) and is the most common type.

  • Uterine Sarcoma: A rarer form that starts in the muscle layer (myometrium) or connective tissues.

Early detection plays a critical role in successful outcomes. Understanding how uterine cancer develops and what risk factors are involved is essential for early diagnosis and prevention.

How Does Uterine Cancer Occur?

Uterine cancer develops when genetic mutations occur in the DNA of uterine cells, causing them to multiply abnormally and avoid natural cell death. Over time, these cells accumulate to form a mass or tumor, which can invade nearby tissues and metastasize to other parts of the body if left untreated.

Factors Responsible for Uterine Cancer

Several factors may contribute to the development of uterine cancer:

  • Hormonal Imbalance: High estrogen levels without adequate progesterone.

  • Age: Most cases are diagnosed in women over 50.

  • Obesity: Increases estrogen production and cancer risk.

  • Diabetes: Linked to a higher risk of endometrial cancer.

  • Genetics: Family history of uterine or colorectal cancer, especially Lynch syndrome.

  • Previous Radiation Therapy: Exposure to pelvic radiation may increase risk.

  • Reproductive History: Never having been pregnant, early menstruation, or late menopause.

  • Hormone Replacement Therapy (HRT): Especially estrogen-only HRT.

Stages and Grades of Uterine Cancer

Stages:

  • Stage I: Confined to the uterus.

  • Stage II: Spread to the cervix.

  • Stage III: Spread to surrounding pelvic tissues.

  • Stage IV: Spread beyond the pelvis to distant organs.

Grades:

  • Grade 1 (Low Grade): Cells resemble normal cells and grow slowly.

  • Grade 2 (Intermediate Grade): More abnormal, moderate growth.

  • Grade 3 (High Grade): Highly abnormal and aggressive.

Types of Uterine Cancer

  • Endometrioid Adenocarcinoma

  • Uterine Papillary Serous Carcinoma

  • Clear Cell Carcinoma

  • Carcinosarcoma

  • Uterine Sarcoma

Signs & Symptoms

Early Signs:

  • Abnormal uterine bleeding

  • Unusual vaginal discharge

  • Pelvic pain

Advanced Symptoms:

  • Pain during intercourse

  • Unexplained weight loss

  • Fatigue

  • Difficulty urinating

Consult a Specialist: Prompt consultation with a gynecologic oncologist is essential if symptoms persist.

Diagnostic Tests & Procedures

Initial Steps:

  • Symptom review and medical history

  • Physical and pelvic examination

Imaging Tests:

  • Transvaginal Ultrasound

  • MRI

  • CT Scan

  • PET Scan

Biopsies:

  • Endometrial Biopsy (Gold Standard)

  • Dilation and Curettage (D&C)

Staging:

  • Additional imaging and lab work to determine the extent of spread

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Available Treatments for Uterine Cancer

At Konkan Cancer Centre, treatment is customized based on stage, grade, and overall health.

1. Surgery:

  • Hysterectomy (total or radical)

  • Bilateral Salpingo-Oophorectomy

  • Lymph Node Dissection

2. Radiation Therapy:

  • External Beam Radiation Therapy (EBRT)

  • Brachytherapy

3. Chemotherapy:

  • Often used in advanced stages or with high-grade tumors

4. Hormone Therapy:

  • Progestins, Tamoxifen, Aromatase Inhibitors

5. Targeted Therapy:

  • Targeting specific cancer cell markers

Gold Standard Treatment:

  • For early-stage: Surgery (Hysterectomy + Salpingo-Oophorectomy)

  • For advanced stages: Surgery + Radiation + Chemotherapy

Most Common FAQs on Uterine Cancer

While not completely preventable, risk can be reduced through lifestyle changes, managing chronic diseases, and regular gynecological check-ups.

Some cases are linked to hereditary syndromes like Lynch syndrome. Genetic counseling is advised if there’s a family history.

Estrogen-only HRT can increase risk. Combined HRT (with progesterone) has a lower risk.

Treatment may cause fatigue, nausea, hair loss, and infection susceptibility. Side effects are managed by your care team.

Initially every 3-6 months, then yearly, based on your oncologist’s advice.

A balanced, anti-inflammatory diet supports healing. Avoid processed foods and stay hydrated.

Fertility is impacted by most treatments. Discuss fertility preservation options before beginning treatment.

Konkan Cancer Centre offers emotional counseling, patient navigation, and support groups.

Conclusion

Uterine cancer, particularly endometrial cancer, can often be treated successfully when caught early. Awareness of symptoms, prompt medical consultation, and a personalized treatment approach significantly improve outcomes.

At Konkan Cancer Centre, we are dedicated to delivering state-of-the-art, compassionate care to every patient. If you or a loved one is experiencing symptoms or has been diagnosed with uterine cancer, contact our team today for expert evaluation and treatment.

Konkan Cancer Centre — Your Partner in Cancer Care.

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